3mers from synthetic genomes vs. 3mers from real genomes as viewed in Skittle

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Below are screen captures of the Skittle repeat map and 3mer display of a synthetic DNA designed to generate the theoretical maximum 3mer patterns. The cause of the maximum 3mer pattern is “ATG” repeated through out a hypothetical synthetic genome. Other repeated codons which would also give the theoretical maximum 3mers are:
“ATC”, “ACG”, “ACT”, “AGT”, “AGC”,
“CAG”, “CAT”, “CGA”, “CGT”,”CTA”, “CTG”,
“GAC”, “GAT”, “GCA”, “GCT”, “GTA”, “GTC”,
“TAC”, “TAG”, “TCA”, “TCG”, “TGA”, “TGC.

Nucleotide display set at 128bp:
atg 128

Nucleotide display set at 2048bp:
atg 2048

Below are screen captures of the Skittle repeat map and 3mer display of a synthetic DNA designed to generate the theoretical minimum 3mer patterns. The cause of the maximum 3mer pattern is “G” repeated through out a hypothetical synthetic genome. Other repeated codons which would also give the theoretical minimum 3mers are repeated “A”, “C”, “T”.

Nucleotide display set at 128bp:

Nucleotide display set at 2048bp:

Below are bursts of maximum 3mers alternated with minimum 3mers.

Below is a synthetic genome of randomly scrambled nucleotides of 25% Adenine, 25% Cytosine, 25% Guanine, 25% Thymine.

Below is a synthetic genome of randomly scrambled nucleotides with a biased proportion of 0% Adenine, 50% Cytosine, 50% Guanine, 0% Thymine.

Below is a synthetic genome of randomly scrambled nucleotides with a biased proportion of 20% Adenine, 30% Cytosine, 30% Guanine, 20% Thymine.

Below is a synthetic genome of randomly scrambled triplets (technically not codons since these include reverse complemented codons) according to an inferred triplet bias of 64 triplets in an E. coli annotation file:

Below is a real E. coli genome.